Endocrine Abstracts

Background: Little is known about the long-term outcome of the thyroid function in Graves’ disease in a large epidemiological setting.Objective: The aim was to evaluate the long-term outcome of the thyroid function in patients diagnosed with Graves’ disease in Denmark in the period 1995-2018. Our research objectives were to investigate the incidence of disease, use of antithyroid drugs, radioactive iodine, thyroidectomy and levothyroxine during...

The G protein-coupled receptor (GPCR), follicle stimulating hormone receptor (FSHR) plays a critical role in ovarian function and reproduction, with multiple functions in follicle growth, maturation, survival, and steroid hormone production. Yet how FSH/FSHR mediates these pleiotrophic physiological roles remains unknown. Numerous studies indicate GPCRs can regulate and diversify their actions through receptor-receptor association and the formation of dimers/oligomers. Moreove...

Background: Adrenal incidentalomas (AI), the finding of asymptomatic adrenal lesion on unrelated imaging, represent an increasing number of endocrine referrals. In 2022, we introduced a nurse-led pathway to manage AI.Aim: To assess the cost savings and patient experience of a telephone nurse-led AI service at Musgrove Park Hospital.Methods: Records for patients seen in the AI clini...

Introduction: Paediatric obesity is increasing globally. By 2050, obesity is expected to cost the UK NHS £10 billion annually.1 Physical activity and exercise are recognised interventions to reduce BMI.2 However, the physiological response to exercise is not understood. Understanding physiological responses in people with obesity (PwO) can inform the prescription of safe rehabilitation exercise programmes. This pilot study explored t...

Introduction/Background: Adrenal incidentaloma is defined as an asymptomatic adrenal mass greater than 1 cm, discovered during imaging performed for another purpose1. The main goal when discovering such a tumor is to rule out a hormonally active lesion or a malignant condition. Radiological characteristics on non-contrast CT or MRI can help to determine if a lesion is benign. If the lesion nature remains indeterminate after these exams, it is recomm...

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are an extremely heterogenous group of diseases with complicated treatment and management decisions. For example, patients with Multiple Endocrine Neoplasia Type 1 (MEN1)-associated gastrinomas present with more aggressive tumors and poorer outcomes. Recent work has shown that sequencing (transcriptomic, proteomic) can phenotype GEP-NETs to accurately reflect important clinical parameters such as tumor aggress...

Background: Metastatic paragangliomas (PGL) and pheochromocytomas (PCC) are rare neuroendocrine diseases with an incidence of 2 to 8 people per million, a prevalence between 1:2500 and 1:6500 and a strong hereditary disposition. However, due to the rarity of the disease, there is relatively limited data on treatment options, including radionuclide therapy using radioisotope analogs of MIBG and dotatate. There are a few published small series on clinical benefits of treating PG...

Background: Hypopituitarism is common in patients with pituitary tumors. Still, the influence of pituitary tumor surgery on gonadal function and reproductive health remains underexplored.Objective: a) To assess gonadal function and its impact on quality of life (QoL) in patients with non-functioning pituitary adenomas (NFPA) before and after transsphenoidal surgery (TSS), b) to identify factors that predict recovery of gonadal function following TSS, and...

A 23-year-old gentleman with a 9-month history of extreme tiredness, muscle aches and pains, weight gain, cold intolerance and constipation presented to hospital with severe lethargy and dizziness and vacant episodes of increasing frequency. Initial examination revealed him to have a pulse rate of around 66 beats per minute. He was haemodynamically stable. A resting ECG showed an elevated ST segment of more than 2 mm with descent to an upward convexity to an inverted T wave es...

Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 1...